Publications

21. Patkulkar PA, Subbalakshmi AR, Jolly MK, Sinharay S. Mapping spatiotemporal heterogeneity in tumor profiles by integrating high-throughput imaging and OMICS analysis. ACS Omega. 2023. https://doi.org/10.1021/acsomega.2c06659

20. Martinez-Orengo N, Tahmazian S, Lai J, Wang Z, Sinharay S, Schreiber-Stainthorp W, Basuli F, Maric D, Reid W, Shah S, Hammoud DA. Assessing organ-level immunoreactivity in a rat model of sepsis using TSPO PET imaging. Front Immunol. 2022 Nov 10;13:1010263. https://doi.org/10.3389/fimmu.2022.1010263. 

19. Shah S, Sinharay S, Patel R, Solomon J, Lee JH, Schreiber-Stainthorp W, Basuli F, Zhang X, Hagen KR, Reeder R, Wakim P. PET imaging of TSPO expression in immune cells can assess organ-level pathophysiology in high-consequence viral infections. Proceedings of the National Academy of Sciences. 2022 119:e2110846119. https://doi.org/10.1073/pnas.2110846119

18. Sinharay S*, Srinivasula S*, Schreiber-Stainthorp W, Shah S, Degrange P, Bonvillain A, Wang J, Dodd L, Carrasquillo JA, Hammoud DA, Di Mascio M. Monitoring Immune Activation with Whole-Body Fluorodeoxyglucose–Positron-Emission Tomography in Simian Immunodeficiency Virus–Infected Rhesus Macaques. ImmunoHorizons, 2021 5:557-67. doi.org/10.4049/immunohorizons.2100043

17. Sinharay S, Tu T, Kovacs ZI, Schreiber-Stainthorp W, Sundby M, Zhang X, Papadakis GZ, Reid WC, Frank JA, Hammoud DA. In vivo imaging of sterile microglial activation in rat brain after disrupting the blood-brain barrier with pulsed focused ultrasound: [18F]DPA-714 PET study. J Neuroinflammation, 2019 16:155. doi.org/10.1186/s12974-019-1543-z
 
16. Heiss JD, Lungu C, Hammoud DA, Herscovitch P, Ehrlich DJ, Argersinger DP, Sinharay S, Scott G, Wu T, Federoff HJ, Zaghloul KA. Trial of magnetic resonance–guided putaminal gene therapy for advanced Parkinson's disease. Movement Disorders, 2019 34:1073-8. doi.org/10.1002/mds.27724
 
15. Shah S, Sinharay S, Matsuda K, Schreiber-Stainthorp W, Muthusamy S, Lee D, Wakim P, Hirsch V, Nath A, Di Mascio M, Hammoud DA. Potential mechanism for HIV-associated depression: upregulation of serotonin transporters in SIV-infected macaques detected by 11C-DASB PET. Frontiers in psychiatry, 2019 10:362. doi.org/10.3389/fpsyt.2019.00362
 
14. Hammoud DA, Sinharay S, Shah S, Schreiber-Stainthorp W, Maric D, Muthusamy S, Lee DE, Lee CA, Basuli F, Reid WC, Wakim P. Neuroinflammatory Changes in Relation to Cerebrospinal Fluid Viral Load in Simian Immunodeficiency Virus Encephalitis. mBio, 2019 10:e00970-19. doi: 10.1128/mBio.00970-19 (F1000 prime Recommended)
 
13. Sinharay S,* Riggle BA,*Schreiber-Stainthorp W, Munasinghe JP, Maric D, Miller LH, Pierce SK, Hammoud DA. MRI demonstrates glutamine-antagonist mediated reversal of cerebral malaria pathology in mice. Proc Nat Acad Sci USA, 2018 115:E12024-E12033. doi: 10.1073/pnas.1812909115
 
12. Schreiber-Stainthorp W, Sinharay S, Srinivasula S, Shah S, Wang J, Dodd L, Lane C, Dimascio M, Hammoud DA. Brain 18F-FDG PET of SIV-infected macaques after treatment interruption or initiation. J Neuroinflammation, 2018 15:207. doi: 10.1186/s12974-018-1244-z
 
11. Hammoud DA, Sinharay S, Steinbach S, Wakim PG, Geannopolous KT, Dey A, Mehta NN, Rapoport S, Snow J, Smith B, Nath A. Global and regional hypometabolism on FDG PET in optimally-treated HIV positive patients with and without neurocognitive dysfunction. Neurology, 2018 91:e1591-e1601. doi: 10.1212/WNL.0000000000006398
 
10. Sinharay S, Lee D, Shah S, Muthusamy S, Papadakis G, Zhang X, Maric D, Reid WC, Hammoud DA. Cross-sectional and longitudinal small animal PET shows pre and post-synaptic striatal dopaminergic deficits in an animal model of HIV. Nucl Med Biol, 2017 55:27-33. doi: 10.1016/j.nucmedbio.2017.08.004
 
9. Casas R, Muthusamy S, Wakim SP, Sinharay S, Lentz MR, Reid WC, Hammoud DA. MR brain volumetric measurements are predictive of neurobehavioral impairment in the HIV-1 transgenic rat. Neuroimage Clin, 2017 17:659-666. doi:10.1016/j.nicl.2017.11.018

8. Sinharay S, Randtke EA, Howison CM, Ignatenko NA, Pagel MD. Detection of in vivo KLK-6 enzyme activity and inhibition using catalyCEST MRI. Molec Imaging Biol, 2018 20:240-248. doi: 10.1007/s11307-017-1092-8
 
7. Sinharay S, Howison CM, Baker AF, Pagel MD. Detecting in vivo urokinase plasminogen activator activity with a catalyCEST MRI contrast agent. NMRBiomed, 2017 30:e3721. doi: 10.1002/nbm.3721 (Journal cover)
 
6. Sinharay S, Randtke EA, Jones KM, Howison CM, Chambers SK, Kobayashi H, Pagel MD. Noninvasive detection of enzyme activity in tumor models of human ovarian cancer using catalyCEST MRI. Magn Reson Med, 2017 77:2005- 2014. doi: 10.1002/mrm.26278
 
5. Sinharay S, Fernandez-Cuervo G, Acfalle JP, Pagel MD. Detection of sulfatase enzyme activity with a catalyCEST MRI contrast agent. Chemistry Euro J, 2016 22:6491-6495. doi: 10.1002/chem.201600685
 
4. Fernández Cuervo G, Sinharay S, Pagel MD.A catalyCESTMRI contrast agent that can simultaneously detect two enzyme activities. ChemBioChem, 17:383-387 (Inside Journal cover)

3. Sinharay S,* Chang TM,* Astashkin AV, Tomat E. Prodigiosin analogue designed for metal coordination: Stable zinc and copper pyrrolyldipyrrins. Inorg Chem, 2014 53:7518-7526. doi: 10.1021/ic5008439
 
2. Sinharay S, Hammoud DA. Brain PET imaging: Value for understanding pathophysiology of HIV- associated neurocognitive disorder (HAND). Curr HIV/AIDS Rep, 2019, doi: 10.1007/s11904-019- 00419-8.
 
1. Sinharay S, Pagel MD. Advances in magnetic resonance imaging contrast agents for biomarker detection. Ann Rev Anal Chem, 2016 112; 9:95-115. doi: 10.1146/annurev-anchem-071015-041514